上海老年脑健康队列研究
上海东方脑医学基金会
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裴钢，男，汉族，1953年12月出生于辽宁省沈阳市，1982年1月加入中国共产党。1981年于沈阳药科大学获学士学位，1984获硕士学位，1991年获美国北卡大学生物化学和生物物理学博士学位，其后在美国杜克大学进行博士后研究，1995年应聘担任中科院和德国马普学会共同支持的青年科学家小组组长。

著名的细胞生物学家，中国科学院院士，发展中国家科学院院士（TWAS）。中国细胞生物学会（CSCB）理事长、中药全球化联盟副主席、Cell Research主编。

担任国家重点基础研究发展计划（973计划）第四届、第五届专家顾问组成员，“发育与生殖研究”重大科学研究计划专家组组长，国家重大基础平台建设专家组成员。

上海市第十三届、十四届人大代表，曾任中国科学院上海生命科学研究院院长、同济大学校长。

目前研究方向
1、G蛋白偶联受体的信号转导及其与其他细胞信号通路间的相互作用；
2、G蛋白偶联受体在神经退行性病变等疾病发展过程中的作用；
3、干细胞和细胞重编程的化学生物学；
4、传统中草药的作用机理研究。

研究成果
研究组在Cell, Nature, Nature Medicine, Nature Immunology, Molecular Cell等国际性学术期刊上发表论文100多篇，并多次获得科研类奖项。
“G蛋白偶联受体信号与其它细胞信号通路间的对话机制”获2006年上海市自然科学一等奖；2007年获得国家自然科学奖二等奖。
“蛋白激酶在阿片类物质介导神经信号的转导和赖受依赖中的作用”获2002年国家自然科学二等奖。
“阿片类药物耐受和成瘾的分子机制研究”获2001年（首届）中华医学科技奖一等奖。
“阿片受体磷酸化及其对受体信号转导的调控机制”获2001年上海市科技进步一等奖。
“孤啡肽受体及阿片受体的信号传导机理研究”获1998年度中华人民共和国教育部科学技术进步奖一等奖。
完成的“发现β抑制因子-1是调节CD4+T细胞存活和自身免疫性的关键因子”这一研究成果还被评为2007年度中国基础研究十大新闻之一。

代表性论文

  1. Li X, Cui J, Yu Y, Li W, Hou Y, Wang X, Qin D, Zhao C, Yao X, Zhao J, Pei G. Traditional Chinese nootropic medicine Radix Polygalae and its active constituent Onjisaponin B reduce β-amyloid production and improve cognitive impairments. PLoS One 2016; 11: e0151147.
  2. Cheng L, Gao L, Guan W, Mao J, Hu W, Qiu B, Zhao J, Yu Y, Pei G. Direct conversion of astrocytes into neuronal cells by drug cocktail. Cell Res 2015; 25: 1269-72.
  3. Hu W, Qiu B, Guan W, Wang Q, Wang M, Li W, Gao L, Shen L, Huang Y, Xie G, Zhao H, Jin Y, Tang B, Yu Y, Zhao J, Pei G. Direct conversion of normal and Alzheimer's disease human fibroblasts into neuronal cells by small molecules. Cell Stem Cell 2015; 17: 204-12.
  4. Cui J, Wang X, Li X, Wang X, Zhang C, Li W, Zhang Y, Gu H, Xie X, Nan F, Zhao J, Pei G. Targeting the γ-/β-secretase interaction reduces β-amyloid generation and ameliorates Alzheimer's disease-related pathogenesis. Cell Discovery 2015; 1:15021.
  5. Mao J, Huang S, Liu S, Feng XL, Yu M, Liu J, Sun YE, Chen G, Yu Y, Zhao J, Pei G. A herbal medicine for Alzheimer's disease and its active constituents promote neural progenitor proliferation. Ageing Cell 2015; 14: 784-96.
  6. Cheng L, Hu W, Qiu B, Zhao J, Yu Y, Guan W, Yang W, Pei G. Generation of Neural Progenitor Cells by Chemical Cocktails and Hypoxia. Cell Res 2014; 24:665-79.
  7. Hou Y, Wang Y, Zhao J, Li X, Cui J, Ding J, Wang Y, Zeng X, Ling Y, Shen X, Chen S, Huang C, Pei G. Smart soup, a traditional Chinese medicine formula, ameliorates amyloid pathology and related cognitive deficits. PLoS One 2014; 9:e111215.
  8. Li H, Yue R, Wei B, Gao G, Du J, and Pei G. Lysophosphatidic acid acts as a nutrient-derived developmental cue to regulate early hematopoiesis. EMBO J 2014; 33: 1383-96.
  9. Li J, Wei B, Guo A, Liu C, Huang S, Du F, Fan W, Bao C, Pei G. Deficiency of beta-arrestin1 ameliorates collagen-induced arthritis with impaired TH17 cell differentiation. Proc Natl Acad Sci USA 2013; 110: 7395-400.
  10. Liu X, Zhao X, Zeng X, Bossers K, Swaab DF, Zhao J, Pei G. β-arrestin1 regulates γ-secretase complex assembly and modulates amyloid-β pathology. Cell Res 2013; 23:351-65.
  11. Yue R, Li H, Liu H, Li Y, Wei B, Gao G, Jin Y, Liu T, Wei L, Du J, Pei G. Thrombin receptor regulates hematopoiesis and endothelial-to-hematopoietic transition. Dev Cell 2012; 22:1092-100.
  12. Chen T, Shen L, Yu J, Wan H, Guo A, Chen J, Long Y, Zhao J and Pei G. Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells. Aging Cell 2011; 10:908-911.
  13. Zhuang L, Hu W, Xin S, Zhao J and Pei G. β-arrestin-1 protein represses adipogenesis and inflammatory responses through its interaction with peroxisome proliferator-activated receptor-γ (PPARγ). J Biol Chem 2011; 286:28403-13.
  14. Zhuang L, Hu W, Zhang M, Xin S, Jia W, Zhao J and Pei G. β-arrestin-1 protein represses diet-induced obesity. J Biol Chem 2011; 286:28396-402.
  15. Chen T, Yuan D, Wei B, Jiang J, Kang J, Ling K, Gu Y, Li J, Xiao L, Pei G. E-cadherin-mediated cell-cell contact is critical for induced pluripotent stem cell generation. Stem Cells 2010; 28:1315-25.
  16. Teng L, Zhao J, Wang F, Ma L, Pei G. A GPCR/secretase complex regulates β- and γ-secretase specificity for Aβ production and contributes to AD pathogenesis. Cell Res 2010; 20:138-53.
  17. Yue R, Kang J, Zhao C, Hu W, Tang Y, Liu X, Pei G. β-arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression. Cell 2009; 139:535-46.
  18. Du C, Liu C, Kang J, Zhao G, Ye Z, Huang S, Li Z, Wu Z, Pei G. MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nature Immunol 2009; 10:1252-9.
  19. Huang J, Chen T, Liu X, Jiang J, Li J, Li DS, Liu XS, Li W, Kang J, Pei G. More synergetic cooperation of Yamanaka factors in induced pluripotent stem cells than in embryonic stem cells. Cell Res 2009; 19:1127–1138.
  20. Luan B, Zhao J, Wu HY, Duan BY, Shu GW, Wang XY, Li DS, Jia WP, Kang JH, Pei G. Deficiency of a β-arrestin2 signal complex contributes to insulin resistance. Nature 2009; 457:1146-9.
  21. Yu MC, Su LL, Zou L, Zang JW, Pei G, Ge BX. An essential function for β-arrestin2 in the inhibitory signaling of natural killer cells. Nat Immunol 2008; 9:898-907.
  22. Zou L, Yang R, Chai J, Pei G. Rapid xenograft tumor progression in β-arrestin1 transgenic mice due to enhanced tumor angiogenesis. FASEB J 2008; 22:355-64.
  23. Shi Y, Feng Y, Kang J, Liu C, Li Z, Li D, Cao W, Qiu J, Guo Z, Bi E, Zang L, Lu C, Zhang JZ, Pei G. Critical regulation of CD4+ T cell survival and autoimmunity by β-arrestin 1. Nat Immunol 2007; 8:817-24.
  24. Ni Y, Zhao X, Bao G, Zou L, Teng L, Wang Z, Song M, Xiong J, Bai Y, Pei G. Activation of β2-adrenergic receptor stimulates γ-secretase activity and accelerates amyloid plaque formation. Nature Med 2006; 12:1390-6.
  25. Wang YY, Tang YW, Teng L, Wu YL, Zhao XH, Pei G. Association of β-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. Nature Immunol 2006; 7:139-47.
  26. Luan B, Zhang ZN, Wu YL, Kang JH and Pei G. β-Arrestin2 functions as a phosphorylation-regulated suppressor of UV-induced NF-γB activation. EMBO J 2005; 24:4237-46.
  27. Kang J, Shi Y, Xiang B, Qu B, Su W, Zhu M, Zhang M, Bao G, Wang F, Zhang X, Yang R, Fan F, Pei G, Ma L. A nuclear function of β-arrestin1: regulation of histone acetylation and gene transcription. Cell 2005; 123:833-47.
  28. Guan JS, Xu ZZ, Gao H, He SQ, Ma GQ, Sun T, Wang LH, Zhang ZN, Lena I, Kitchen I, Elde R, Zimmer A, He C, Pei G, Bao L, Zhang X. Interaction with vesicle luminal protachykinin regulates surface expression of delta-opioid receptors and opioid analgesia. Cell 2005; 122:619-31.
  29. Gao H, Sun Y, Wu Y, Luan B, Wang Y, Qu B, Pei G. Identification of β-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-κB pathways. Mol Cell 2004; 14:303-17.
  30. Wang P, Gao H, Ni Y, Wang B, Wu Y, Ji L, Qin L, Ma L, Pei G. β-Arrestin2 functions as a GPCR-activated regulator of onco-protein Mdm2. J Biol Chem 2003; 278:6363-70.
  31. Xu NJ, Bao L, Fan HP, Bao GB, Pu L, Lu YJ, Wu CF, Zhang X, Pei G. Morphine withdrawal increases glutamate uptake and surface expression of glutamate transporter GLT1 at hippocampal synapses. J Neurosci 2003;23:4775-84.
  32. Pu L, Bao GB, Xu NJ, Ma L, Pei G. Hippocampal long-term potentiation is reduced by chronic opiate treatment and can be restored by re-exposure to opiates. J Neurosci 2002; 22:1914-21.
  33. Sun Y, Cheng Z, Ma L, Pei G. β-arrestin2 is critically involved in CXCR4-mediated chemotaxis and this is mediated by its enhancement of p38 MAPK activation. J Biol Chem 2002; 277:49212-9.
  34. Cheng ZJ, Zhao J, Sun Y, Hu W, Wu YL, Cen B, Wu GX, Pei G. β-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4. J Biol Chem 2000;275:2479-85.
  35. Jing Q, Xin SM, Zhang WB, Wang P, Qin YW, Pei G. Lysophosphatidycholine activates p38 and p42/44 mitogen-activated protein kinases in monocytic THP-1 cells, but only p38 activation is involved in its stimulated chemotaxis. Circ Res 2000; 87:52-59.
  36. Zhao J, Ben LH, Wu YL, Hu W, Ling K, Xin SM, Nie HL, Ma L, Pei G. Anti-HIV agent trichosanthin enhances the capabilities of chemokines to stimulate chemotaxis and G protein activation, and this is mediated through interaction of trichosanthin and chemokine receptors. J Exp Med 1999; 190:101-11.
  37. Ling K, Wang P, Zhao J, Wu YL, Cheng ZJ, Wu GX, Hu W, Ma L, Pei G. Five-transmembrane domains appear sufficient for a G protein-coupled receptor: functional five-transmembrane domain chemokine receptors. Proc Natl Acad Sci 1999; 96:7922-7.
  38. Jing Q, Xin SM, Cheng ZJ, Zhang WB, Zhang R, Qin YW, Pei G. Activation of p38 mitogen-activated protein kinase by oxidized LDL in vascular smooth muscle cells: mediation via pertussis toxin-sensitive G proteins and association with oxidized LDL-induced cytotoxicity. Circ Res 1999; 84:831-9.